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KMID : 0604520180440010073
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Journal of the Society of Cosmetic Scientists of Korea
2018 Volume.44 No. 1 p.73 ~ p.79
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Primary Cilia, A Novel Bio-target to Regulate Skin Pigmentation
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Choi Hyun-Jung
Park Nok-Hyun
Kim Ji-Hyun
Cho Dong-Hyung
Lee Tae-Ryong
Kim Hyoung-June
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Abstract
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The primary cilium protrudes from the cell body like a bio-antenna that has many receptors, channels and signaling molecules to sense and response to external stimuli. The external environment such as ultraviolet irradiation, temperature, humidity, gravity and shear stress always influences skin. Skin responds to external stimuli and differentiates by making melanin, collagen and horny layer. Ciliogenesis participates in developmental processes of skin, such as keratinocyte differentiation and hair formation. And it was reported that skin pigmentation was inhibited when ciliogenesis was induced by sonic hedgehog-smoothened-GLI2 signaling. When skin is exposed to ultraviolet irradiation, alpha-melanocyte stimulating hormones (α-MSH) increase melanin synthesis through activation of the cAMP pathway in melanocytes. We observed that α-MSH and cAMP production inducers inhibited ciliogenesis of melanocytes. Therefore, we thought that regulation of ciliogenesis is potential candidate target for the development of agents to treat undesirable hyperpigmentation of skin. As a result, we found out that an ethanol extract of Glycyrrhiza glabra (EGG) root and 3,4,5-trimethoxy cinnamate thymol ester (TCTE, Melasolv) significantly inhibit melanin synthesis of normal human melanocyte by inducing primary cilium formation. This study proposed new theory to regulate skin pigmentation and cosmetic components for skin whitening.
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KEYWORD
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Primary cilia, melanogenesis, Smo-GLI2 signaling, skin whitening
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